The Question: Does coffee consumption as measured by serum levels of paraxanthine, a caffeine metabolite, increase the risk of spontaneous abortion?
Answer in a nutshell: Only extremely high serum paraxanthine concentrations are associated with spontaneous abortion, suggesting that moderate consumption of caffeine (up to 5 cups of coffee a day) is unlikely to increase the risk of spontaneous abortion.
Whether consumption of caffeine during pregnancy increases the risk of spontaneous abortion is controversial. Several studies have indicated that even moderate caffeine consumption is associated with a risk of fetal loss whereas some have found no increase in risk even among women who consume large amounts of caffeine. Many factors including methodological flaws could have led to these conflicting results. Wide variations in individual rates of caffeine metabolism make it difficult to translate even an accurately reported intake into serum concentrations of caffeine and its metabolites. In this study, the authors used a biological marker, serum paraxanthine, a metabolite of caffeine, to measure the dose of caffeine.
Stillbirth coffee study
Groups with varying amounts of coffee consumption: Risk increase of stillbirth compared to group 1 as a control group
group 2 (1-3 cups per day) - 30%
group 3 (4-7 cups per day) 80%
group 4 (8 or more cups per day) 300%
The surprising result was that a small amount of coffee (1-3 cups per day) was actually reducing the risk of stillbirth by 30% when compared to women who drank no coffee at all. However, from 4 cups of coffee per day or more there was a sharp increase of stillbirths within the first year (=sum of stillbirths and deaths within the first year of life).
The authors suggest that physicians should advise their pregnant patients to limit coffee consumption in pregnancy to 1 or 2 cups of coffee or the equivalent of caffeinated drinks per day as a precautionary measure.
this should in no way be used as a means to abort an unwanted baby. these studies are meant to educate expecting mothers about the dangers of too much caffeine.
Posted: 30 Sep 23:29